Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.
نویسندگان
چکیده
منابع مشابه
Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer
The tumor necrosis factor alpha (TNF-alpha) gene was introduced by retroviral gene transfer into the TNF-alpha-insensitive tumor cell line J558L. Production of 40 pg/ml TNF-alpha by clone J2T12 consistently did not change the growth rate in vitro, but drastically suppressed tumor growth when injected into syngeneic BALB/c mice. Within 2 wk, 90% of the mice inoculated with J558L cells developed ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1991
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.173.5.1047